Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

in European Journal of Endocrinology
View More View Less
  • 1 A Subramanian, Institute of Applied Health Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom of Great Britain and Northern Ireland
  • 2 J Idkowiak, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, B152TT, United Kingdom of Great Britain and Northern Ireland
  • 3 K Toulis, College of Medical and Dental Sciences , University of Birmingham Institute of Applied Health Research, Birmingham, United Kingdom of Great Britain and Northern Ireland
  • 4 S Thangaratinam, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland
  • 5 W Arlt, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom of Great Britain and Northern Ireland
  • 6 K Nirantharakumar, Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland

Correspondence: Jan Idkowiak, Email: j.idkowiak@bham.ac.uk

Context: The incidence of gestational diabetes mellitus (GDM) has been on the rise, driven by maternal obesity. In parallel, pubertal tempo has increased in the general population, driven by childhood obesity.

Objective: To evaluate the available evidence on pubertal timing of boys and girls born to mothers with GDM.

Data Sources: We searched MEDLINE, EMBASE, CINAHL Plus, Cochrane library and grey literature for observational studies up to October 2019.

Study selection and extraction: Two reviewers independently selected studies, collected data and appraised the studies for risk of bias. Results were tabulated and narratively described.

Results: Seven studies (six for girls and four for boys) were included. Study quality score was mostly moderate (ranging from 4 to 10 out of 11). In girls born to mothers with GDM, estimates suggest earlier timing of pubarche, thelarche and menarche although for each of these outcomes only one study each showed a statistically significant association. In boys, there was some association between maternal GDM and earlier pubarche, but inconsistency in the direction of shift of age at onset of genital and testicular development and first ejaculation. Only a single study analysed growth patterns in children of mothers with GDM, describing a 3-month advancement in the age of attainment of peak height velocity and a slight increase in pubertal tempo.

Conclusions: Pubertal timing may be influenced by the presence of maternal GDM, though current evidence is sparse and of limited quality. Prospective cohort studies should be conducted, ideally coupled with objective biochemical tests.

If the inline PDF is not rendering correctly, you can download the PDF file here.

 

     European Society of Endocrinology

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 208 208 208
PDF Downloads 140 140 140