In 27 cases of obesity, renal function was examined by clearance methods with a constant plasma level. The results showed that, as compared with normal controls, renal blood flow, glomerular filtration and the filtration fraction were significantly reduced.
Therapy with L-tri-iodothyronine (TIT) covered 17 cases of obesity. The influence of the drug on renal function, total body fluids and extracellular fluids was examined. Statistical probability indicated that total body fluid and glomerular filtration were nearly normalised and renal blood flow was significantly increased while the extracellular fluids volume remained unchanged at a low level.