Induction of anovulatory sterility by neonatal treatment with 5β-dihydrotestosterone in female rats

in European Journal of Endocrinology
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Wistar female rats were injected with testosterone (T) or 5β-dihydrotestosterone (5β-DHT) for the first 5 days of life. Neonatal treatment with 1 mg of T resulted in anovulatory persistent oestrous syndrome in 100% of the animals. In the females injected with 1 mg of 5β-DHT, 74% of the treated rats became sterile at 120 days of age. In addition, 0.5 mg 5β-DHT was also effective in inducing anovulatory persistent oestrus; the incidence of sterility was 10 and 80% at 60 and 120 days of age, respectively. When daily dose of 5β-DHT was reduced to 0.1 mg, however, only 33% of the rats resulted in sterility. These results suggest that the free form of T and non-aromatizable androgen, 5β-DHT, can permanently suppress the development of female type of neuroendocrine regulation. The possible participation of the process other than the central aromatization in androgenization will be discussed.


     European Society of Endocrinology

Sept 2018 onwards Past Year Past 30 Days
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