Androgen excess and diagnostic steroid biomarkers for nonclassic 21-hydroxylase deficiency without cosyntropin stimulation

in European Journal of Endocrinology
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  • 1 Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
  • 2 National Institutes of Health (NIH) Clinical Center, Bethesda, Maryland, USA
  • 3 School of Public Health, University of Michigan, Ann Arbor, Michigan, USA
  • 4 Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA
  • 5 Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA

Correspondence should be addressed to A F Turcu; Email: aturcu@umich.edu

The authors apologise for an error in Table 2 of the above article published in the July 2020 issue (vol 183 Iss 1 pp 63–71) of the European Journal of Endocrinology. The values for 17OHP4 should be as given in the table below and not as published. The correct Table 2 is published in full below.

Table 2

Comparison of steroid concentrations between patients with nonclassic 21-hydroxylase deficiency (N21OHD) and controls. Data are expressed as median (interquartile range).

Steroid (nmol/L)N21OHD (n = 32)Controls (n = 54)Ratio of medians N21OHD/controlsP
17OHP418.1 (8.7–33.0)2.8 (0.9–4.3)6.5<0.0001
16OHP4 2.4 (1.4–4.9)0.6 (0.4–0.9)4.1<0.0001
21dF 1.8 (1.3–5.3)0.0 (0.0–0.3)N/A<0.0001
Progesterone 0.8 (0.5–1.4)0.4 (0.3–0.8)1.80.0018
Cortisol 202.5 (125.9–442.8)249.1 (208.9–373.7)0.80.197
Cortisone 53.7 (30.5–72.3)51.5 (40.3–60.8)1.00.855
Corticosterone1.6 (0.8–3.5)5.9 (3.5–13.6)0.3<0.0001
11dF 0.8 (0.5–1.4)0.9 (0.4–1.6)0.80.626
DOC 0.3 (0.3–0.4)0.5 (0.4–0.9)0.60.113
A4 4.3 (2.0–8.1)3.9 (2.2–8.5)1.10.798
Testosterone 1.1 (0.5–2.7)1.6 (0.8–4.3)0.70.195
11OHA4 9.6 (5.1–25.9)4.5 (2.9–7.1)2.1<0.0001
11KA4 1.1 (0.7–1.7)0.6 (0.4–0.8)1.70.0001
11OHT 1.0 (0.3–1.7)0.4 (0.3–0.6)2.20.0019
11KT 1.8 (1.2–3.3)0.9 (0.6–1.3)2.0<0.0001
11KT/Testosterone1.8 (1.2–3.0)0.6 (0.2–0.9)3.3<0.0001
11OHA4/A42.6 (2.1–4.6)1.2 (0.7–2.1)2.0<0.0001
A4/testosterone3.8 (2.8–4.5)3.5 (2.4–4.2)1.30.274

A4, androstenedione; DOC, 11-deoxycorticosterone; 17OHP4, 17α-hydroxyprogesterone; 16OHP4, 16α-hydroxyprogesterone; 21dF, 21-deoxycortisol; 11dF, 11-deoxycortisol; 11OHA4, 11β-hydroxyandrostenedione; 11KA4, 11-ketoandrostenedione; 11OHT 11β-hydroxytestosterone; 11KT, 11-ketotestosterone.

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