Twin genes and endocrine disease: CYP21 and CYP11B genes

in European Journal of Endocrinology

CYP21 and CYP11B genes have a common feature: they are "twin" genes. It seems as if doubling and subsequent drifting apart rendered these genes particularly sensitive to defect acquisition by mechanisms involving recombinatorial events. This creates specific difficulties in the molecular diagnosis of defects.

 

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