Hypothalamic and pituitary cytosol receptors to 5α-dihydrotestosterone and oestradiol-17β during the prepubertal period in the male lamb

in European Journal of Endocrinology
Author: J. Pelletier
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Abstract.

Hypothalamic and pituitary cytosol receptors to 5α-dihydrotestosterone (DHT) and oestradiol-17β (E2) were measured in the male lamb from 9 to 120 days of age, 24 h after castration. Concentrations of pituitary receptors did not change with age, but the total number of receptors and the pituitary weight showed a parallel increase (P < 0.001). Conversely, there were no marked changes in the total number of hypothalamic receptors but this number was high as early as 9 days of age, 42.4 and 80.0 fmol/hypothalamus for DHT and E2, respectively. These data suggest that the number of hypothalamic and pituitary cytosol receptors to DHT and E2, is not a critical parameter in the succession of events which precedes puberty.

 

     European Society of Endocrinology

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