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  • Author: Won G. Ng x
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Francine Ratner Kaufman, Yan Kang Xu, Won G. Ng, Paul D. Silva, Rogerio A. Lobo and George N. Donnell

Abstract. Evaluation of ovarian steroid secretion, histologic examination of ovarian tissue, and incubation studies with radiolabelled galactose in ovarian tissue slices were performed in a 21-year-old woman with galactosemia and incipient ovarian failure. After exogenous gonadotropin administration in an attempt to achieve fertility, there was no evidence of ovulation by ultrasound; estrogen and androgen production were deficient indicating ovarian unresponsiveness. Histologic examination of the ovary revealed that the ovarian stroma had an increase in fibrous tissue and that a few hyalinized atretic follicles were present with no intermediate or evolving Graffian follicles. After incubation with galactose-l-14C, there was absence of labelled CO2 production and only labelled galactose-l-phosphate was identified as compared to controls in which several labelled intermediates could be seen. The incorporation of galactose into the TCA-insoluble fraction was drastically reduced in the patient compared to controls, suggesting that there may be a deficiency of ovarian galactose-containing glycolipids, glycoproteins and mucopolysaccharides in the galactosemic ovary. Deficiency in the production of galactose containing compounds, or galactose-phosphate accumulation or both, may lead to the development of hypergonadotropic hypogonadism seen in women with galactosemia.

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Francine Ratner Kaufman, Yan Kang Xu, Won G. Ng, Paul D. Silva, Rogerio A. Lobo and George N. Donnell

We would like to inform the readers of this Journal that duplication of data appeared in our article entitled 'Gonadal function and ovarian galactose metabolism in classic galactosemia', Acta Endocrinol (Copenh) 1989; 120: 129–33, with data published in 'Galactose metabolism in human ovarian tissue', Pediatr Res 1989; 25: 151–5. We sincerely regret this occurrence. Fig. 2 in Acta Endocrinologica was duplicated from Fig. 1 of Pediatric Research. In addition, the data from Table 2 in Acta Endocrinologica and from Table 1 in Pediatric Research, derived from the same patient and experiments, showed discrepancies which are at erratum. In Table 2 in Acta Endocrinologica, the range of the TCA-insoluble fraction with labelled galactose, should be 92–290 cpm/mg and of CO2 production with labelled galactose, it is 141–196 cpm/mg.