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E. Rolandi and T. Barreca


In 18 female patients affected by advanced breast cancer, the serum prolactin (PRL) levels have been determined under basal conditions and after the administration of analgesic opiates such as methadone and pentazocine. A significant increase of prolactin serum values was found after the use of both drugs. This finding is considered to be of clinical importance.

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E. Rolandi, R. Franceschini, A. Marabini, V. Messina, A. Cataldi, M. Salvemini and T. Barreca

Abstract. A chronobiological study was carried out in seven elderly male subjects (78–84 years) to evaluate the 24-h beta-endorphin secretory pattern. Seven young adult males (28–37 years) made up the control group. Blood samples were drawn every four hours from 08.00 to 20.00 h and every two hours from 24.00 to 06.00 h. ACTH and cortisol levels were also determined in the same plasma samples. Mean 24-h beta-endorphin values in the elderly (32.6 ± 1.1 ng/l) and in the young adult male subjects (29.5 ± 1.4 ng/l) did not differ statistically, but the circadian rhythm was absent in the elderly subjects. In the elderly, plasma ACTH and cortisol concentrations showed a circadian rhythm similar to that observed in the adult subjects. However, in the elderly patients, in contrast to that in the adult subjects, the multilinear regression analysis did not show any statistically significant correlation between the beta-endorphin, ACTH and cortisol 24-h plasma concentrations.

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T. Barreca, R. Franceschini, C. Siani, C. Perria, N. Franca viglia, A. Cataldi and E. Rolandi

Abstract. Somatostatin concentration was determined in plasma and in cerebrospinal fluid during a 24-h period in 7 male patients suffering from hydrocephalus of differing aetiologies. Blood and ventricular cerebrospinal fluid samples were taken every 2 h during the day (08.00–22.00 h) and every hour during the night (24.00–07.00 h). Simultaneously, plasma growth hormone levels were also evaluated. Plasma SRIH levels showed significant circadian variations with highest values in the daytime and lowest values during the night. Cerebrospinal fluid SRIH did not show any significant time-related circadian changes. Plasma GH levels showed the well-known circadian pattern in the majority of patients. No significant correlation was found between the plasma GH and plasma or cerebrospinal fluid SRIH values recorded during the 24-h period. Results suggest that peripheral SRIH does not play any major role in the control of the 24-h GH secretory pattern in man.

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T. Barreca, R. Franceschini, C. Siani, C. Perria, N. Francaviglia, A. Cataldi and E. Rolandi

Acta Endocrinol (Copenh) 1988, 117: 130–134

Page 133, Table 1 should read:

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