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  • Author: Stefan Zgliczyński x
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Stefan Zgliczyński and Marek Kaniewski

Abstract.

In order to elucidate the role of the adrenergic nervous system in the mechanism of TSH release in men the effects of α- and β-receptors blocking agents were studied in 11 healthy volunteers. Phentolamine administetred iv as a bolus injection in a dose of 10 mg, significantly lowered the TSH release in basal condition and in response to TRH stimulation. However, propranolol in a dose of 0.1 mg/kg administered in the same fashion as phentolamine had no effect on the TSH secretion. The results obtained suggest that the α-receptors of the adrenergic system are involved in the physiological mechanism which stimulates TSH release in men.

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Piotr Soszyński, Stefan Zgliczyński and Jolanta Pucilowska

Abstract. In order to determine the influence of thyroid function on the pineal gland in humans, the circadian rhythm of the serum melatonin concentration was estimated in 16 women with thyroid disorders: 8 with hypothyroidism and 8 with hyperthyroidism, as well as in 5 healthy controls. A significant melatonin circadian rhythm was observed in all the three groups studied. The melatonin rhythm parameters derived from cosinor analysis: mesor (controls: 0.163 ± 0.03 nmol/l (± sem), hypothyroid patients: 0.176 ± 0.22 nmol/l, and hyperthyroid patients: 0.167 ± 0.04 nmol), amplitude (0.155, 0.145 and 0.138 nmol/l, respectively), acrophase (1:38, 2:22 and 1:51 h, respectively) did not differ significantly in the three groups studied. Integrated 24-h melatonin secretion was also similar in patients and controls. The melatonin concentrations were positively correlated with TSH levels in hypothyroidism, and negatively correlated with T3 in hyperthyroidism. In conclusion: in patients with hypo- and hyperthyroidism the circadian rhythm of melatonin secretion is not altered.

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Piotr Soszyński, Jadwiga Slowińska-Srzednicka and Stefan Zgliczyński

Abstract.

Atrial natriuretic hormone is involved in the control of blood pressure and water-electrolyte balance. In order to assess the relationship between atrial natriuretic hormone and hypertension in acromegaly, 34 subjects were studied, 18 with acromegaly (10 normotensive and 8 hypertensive) and 16 healthy controls. Plasma atrial natriuretic hormone levels, as well as plasma renin activity, aldosterone and growth hormone levels were measured in basal conditions in all subjects. Additionally, plasma renin activity and aldosterone levels were determined after standard stimulation. In hypertensive acromegalic patients, atrial natriuretic hormone plasma concentrations (39.8±3.5 ng/l) were significantly higher than in patients without hypertension (27.9±4.1 ng/l), and in controls (28.6±1.3 ng/l) (p<0.01 in both comparisons). Stimulated plasma renin activity values were decreased in hypertensive acromegalic patients when compared with those in normotensive patients (1.14±0.29 vs 4.03±0.66 μg·l−1 ·h−1, p<0.01). In acromegaly, atrial natriuretic hormone levels correlated with mean arterial pressure (r=0.58, p=0.01). These results suggest that atrial natriuretic hormone plasma levels are slightly increased in patients with acromegaly and hypertension.