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A Malamitsi-Puchner, IE Messinis, V Sakellariou, E Economou and S Michalas

OBJECTIVE: To study the association between the circulating concentrations of endothelin-3 and prolactin in the early puerperium. DESIGN: Prospective clinical study, including twenty-five healthy puerperal women breast-feeding their healthy full-term infants. METHODS: Venous blood was drawn on day 1 and 4 post partum, and plasma endothelin-3 and serum prolactin were determined. RESULTS: Circulating endothelin-3 and prolactin levels on day 4 did not differ significantly from the corresponding levels on day 1. However, a significant negative correlation was found on day 4 between endothelin-3 and prolactin values (r = -0.688, P < 0.001) and an even stronger negative association existed between the net change in endothelin-3 from days 1 to 4 and the corresponding change in prolactin values (r = -0.732, P < 0.001). CONCLUSIONS: On the fourth day post partum, lactating healthy women show negative correlation between circulating endothelin-3 and prolactin levels. Whether this indicates a role for endothelin-3 in the control of prolactin secretion in the post partum period remains to be clarified.

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Ch. Zoupas, E. Mastrantonakis, I. Diakakis, G. Fakas, S. Michalas, N. Kalpogiannis, D. Aravantinos and D. Kaskarelis

Gestational diabetes is defined as a disturbed carbohydrate metabolism present during pregnancy but reverting to normal after delivery. It constitutes a current social problem since it may occur in 2 - 3% of pregnancies and the incidence may be much greater in selected populations (Freinkel & Josimovich 1980). The known impact of this condition on perinatal mortality, foetal macrosomia and neonatal hypoglycaemia have dictated the need for an increased awareness, improved identification and special therapeutic management. Since the best therapeutic management of women with gestational diabetes, has not yet been established, we decided to investigate the following groups of pregnant women on the basis of upper normal limits of fasting blood sugar (FBS) 105 mg% (Metzger et al. 1981). Therefore the aim of the present study was to evaluate the effect and the value of insulin administration, once or twice daily, in patients with gestational diabetes.

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