Search Results

You are looking at 1 - 10 of 53 items for

  • Author: Rolf Luft x
Clear All Modify Search
Restricted access

Rolf Luft

Restricted access

ROLF LUFT and BJÖRN SJÖGREN

INTRODUCTION

Simmonds' disease denotes a clinical syndrome, caused by a decrease in all the functions of the adenohypophysis. It has also been called panhypopituitarism. This name is not entirely satisfactory as it also includes a decreased activity of the neurohypophysis. We have preferred to introduce the term panhypoadenopituitarism in our case, as no histological examination could be made, and no signs of deranged function of the neurohypophysis could be found.

In animals the most important effects of hypophysectomy

1) The desoxycorticosterone acetate and testosterone propionate used in this work was Percorten and Perandren, and was kindly put at our disposal by Ciba Produkter A. B., Stockholm.

2) This case was kindly referred to us for treatment by Dr. Gustaf Myhrman, director of the medical department of the military hospital of Boden.

can be eliminated by the administration of pituitary extracts. In cases of panhypoadenopituitarism different types of pituitary

Restricted access

Erol Cerasi and Rolf Luft

ABSTRACT

In a previous paper it was shown that 15 out of 85 healthy subjects with a normal intravenous glucose tolerance demonstrated a low plasma insulin response to glucose infusion which was similar to that obtained in diabetic subjects. In the present paper it has been shown that the type of insulin response to glucose infusion was the same when the test was repeated.

Low insulin responders to glucose infusion, as a group, also showed low insulin response to intravenous tolbutamide and oral glucose. This indicates that the type of insulin response is characteristic for a given subject irrespective of the stimulation used.

There seemed to be no difference in the occurrence of diabetes in the family history of the groups of low and high insulin responders.

Restricted access

ROLF LUFT and BJÖRN SJÖGREN

The term Gynecomastia is used to denote an enlargement of the breast in the male due to hyperplasia of the duct epithelium and periductal stroma. It may be produced by an altered hormone secretion in the testicles and adrenal cortex or a disordered metabolism of these hormones. It is also probable that the end organ might show an increased sensitivity to the hormones mentioned. This latter mechanism has. however, not so far been elucidated.

Gynecomastia has thus been found in cases with tumours (Hunt & Budd, 1939) or degenerative changes of the testicles (Klinefelter et al., 1942, Heller & Nelson, 1945) with or without an increased excretion of oestrogenic or gonadotrophic hormones; in tumours of the adrenal cortex with or without an increased excretion of oestrogens (Bittorf, 1919, Holl, 1930, Broster & Vines, 1933, Lisser, 1936, Simpson & Joll, 1938. Roholm & Teilum, 1942, Mc Fadzean, 1946, Armstrong & Simpson

Restricted access

ROLF LUFT and BJÖRN SJÖGREN

This study concerns the metabolic effect of cortisone, 17-hydroxy-11-dehydrocorticosterone. It is a continuation of our earlier work on the metabolic effect of ACTH peptides (Luft et al., 1949) and ACTH protein (Luft et al., 1950). The aim of the work has been to study the metabolic effect of cortisone under conditions identical with those in the previous work with ACTH, and also to compare the effect of these two hormones.

MATERIAL AND METHODS

Three patients were studied and were kept under careful observation in a metabolic unit in the hospital. They were given a constant diet and a constant supply of fluid during the control and experimental periods. Cortisone was administered in a daily dose of 200 mg., divided into 4 injections, i. e.,

1) These studies were aided by grants from the Medical Research Council of Sweden.

2) The Cortisone was kindly supplied by Ciba Produkter AB, Stockholm.

3)

Restricted access

Denis Ikkos and Rolf Luft

ABSTRACT

Five adult, non-diabetic, hypophysectomized women were given human growth hormone (HGH) in doses of 10–20 mg/d for 2–3 days (total dose 30–60 mg). HGH induced nitrogen retention as well as fasting – and excessive postprandial – hyperglycaemia and glycosuria. These changes disappeared when HGH-treatment was stopped. The findings were interpreted as demonstrating that the development of »idiohypophyseal« diabetes mellitus in human subjects is possible.

Studies with 14C-labelled glucose in these subjects showed that the turnover rate of glucose was decreased by HGH, and that the absolute values for peripheral disposal of glucose were unchanged in three patients, decreased in one and transitorily decreased in the fifth. Since the blood glucose level increased during HGH, the results of the 14C-glucose studies were taken as evidence that peripheral glucose metabolism is depressed by HGH in man.

Restricted access

ROLF LUFT and BJÖRN SJÖGREN

The present study is a continuation of earlier work on the metabolic effect of ACTH peptides, ACTH protein and cortisone (Luft et al., 1949 and 1950, Luft & Sjögren, 1951, 1). Preliminary data on the metabolic effect of DCA have been published elsewhere (Luft & Sjögren, 1951, 2-3).

As is well known, when given for a short period of time DCA results in a retention of sodium, chloride and water as well as a loss of potassium. However, little is known of the effect of DCA during prolonged administration.

The aim of the present work was to study the metabolic effect of DCA when given over a considerable period of time.

  1. Read at the annual meeting of the Swedish Society for Endocrinology in Stockholm on February 16, 1952, and at the 2nd Scandinavian Congres for Endocrinology in Helsingfors on May 23, 1952.
  2. These studies were aided by grants from

Restricted access

Denis Ikkos and Rolf Luft

The demonstration of a species specificity of growth hormone (GH) made it possible to examine the metabolic action of this hormone in man by the use of human growth hormone preparations. The results obtained in our trials will be presented under the subheadings: protein metabolism, calcium metabolism, sodium and chloride metabolism, fat metabolism, ketogenesis, and finally carbohydrate metabolism.

Protein metabolism. Human GH caused protein anabolism as shown by retention of nitrogen, phosphorus and potassium in proportions similar to those found in protoplasm. Retention of these elements appeared promptly upon GH administration and persisted during the whole treatment period. Upon withdrawal of GH the balances of nitrogen, phosphorus and potassium became negative, but the losses during the post-treatment period were smaller than the gains under GH. Previous pathological creatinuria disappeared, and NPN concentration in blood decreased on GH administration.

Calcium metabolism. Increased calciuria appeared in all instances and the calcium balance

Restricted access

ROLF LUFT and BJÖRN SJÖGREN

Disturbed water and salt metabolism is a cardinal symptom in Addison's disease. It causes dehydration of the patient, as well as hypotension and, to some extent, asthenia.

The disturbed fluid balance is manifested by an incapacity to respond in the normal way to rapid changes in the fluid supply. When a fairly large quantity of fluid is administered, e. g., in a water test or with Kepler's test, this is excreted more slowly than normal and the urine does not undergo maximal dilution (Robinson et al., 1941, Levy et al., 1946).

Talbott et al. (1942), in cases of adrenal cortical insufficiency, found a reduced glomerular filtration rate and renal plasma flow, the filtration being proportionately more reduced. These authors also discuss the earlier literature on this subject. Recently Waterhouse & Keutmann (1948) demonstrated a marked reduction of glomerular filtration and renal plasma flow in their cases of Addison's disease.

In