Although the adrenogenital syndrome has been known for about 150 years, it was not until 1950 when Wilkins et al. succeeded in suppressing the excessive adrenal androgen production with cortisone, that a better understanding of the abnormal adrenal function and its treatment was obtained.
This syndrome is caused by hyperplasia of the adrenal cortex or an adrenal cortical tumour. Sometimes nests of adrenal cortical cells situated anywhere from renal to gonad levels, even in the liver, may produce this clinical picture.
As to the frequency of the adrenogenital syndrome, a recent survey (Russel, 1954) gives a total of 275 cases, 215 of which were due to hyperplasia (10 of postnatal origin) and 60 of which were due to tumour (all postnatal). Around 75 % of the cases occurred in females.
All the clinical manifestations can, in the true adrenogenital syndrome, be traced back to an abnormal androgen production, and may be