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Gunnar Stenström, Lars Sjöström, and Ulf Smith

Abstract. Sixty patients undergoing operation for phaeochromocytoma were investigated in the pre- and postoperative states with respect to fasting blood glucose levels. When 6 previously known or suspected diabetics were excluded, preoperative diabetes (fasting blood glucose levels ≥ 7.0 mmol/l) were found in 3 of 13 (23%) with sustained hypertension, in 6 of 12 (50%) with sustained hypertension associated with paroxysms and in 4 of 24 (17%) with paroxysmal hypertension. None of the 5 patients with atypical clinical symptoms had glucose levels ≥ 7.0 mmol/l. In the groups of patients with particularly high urinary excretion of catecholamines and vanilmandelic acid higher blood glucose levels were also found. The postoperative blood glucose levels in the follow-up study were normal and < 5.8 mmol/l in all cases except in 3 of the 4 still living patients with a previously known diabetes and in 1 patient with a malignant tumour.

Thus, manifest diabetes, defined as fasting glucose levels ≥ 7.0 mmol/l, is frequently present in patients with phaeochromocytoma (24% in the present study) and the diabetes is reversed by removal of the tumour.

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Camilla A M Glad, Lena M S Carlsson, Olle Melander, Peter Almgren, Lars Sjöström, Staffan Nilsson, Ingrid Larsson, Per-Arne Svensson, and Gudmundur Johannsson


To test the hypothesis that the GH receptor (GHR) exon 3 deleted (d3)/full-length (fl) polymorphism influences anthropometry and body composition in the general population.

Design and setting

The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A subgroup of the population-based Malmö Diet and Cancer study (MDC-CC) was used as a replication cohort.


The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 years. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 years. GHR d3/fl genotypes were determined using TagSNP rs6873545. Linear regression analyses were used to test for genotype–phenotype associations.


In the SOS reference study, subjects homozygous for the d3-GHR weighed ∼4 kg more (P=0.011), and had larger waist-to-hip ratio (WHR, P=0.036), larger waist circumference (P=0.016), and more fat-free mass estimated from total body potassium (P=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (P=0.002), but not those with other anthropometric traits.


In this population-based study, the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity.