K. MANN, G. SPÖTTL and K. SIDDLE
K. KORALLUS-PRINZ, K. MANN, R. MONCAYO and K. SIDDLE
K. MANN, U. BECHTEL, J. M. GOKEL and K. SIDDLE
K. MANN, G. SPÖTTL, R. CLARA, M. OTT and K. SIDDLE
U. MERKEL, W. E. MERZ, K. MANN and G. SPÖTTL
W. RABL, D. KNORR, F. BIDLINGMAIER, O. BUTENANDT and K. MANN
R. Hörmann, J. Kirner, B. Sailer and K. Mann
Thyroid stimulating antibodies (TSAb) acting in vivo as uncontrolled stimulators of the thyroid are generally accepted to cause hyperthyroidism in Graves' disease (GD). In contrast, under in vitro conditions Graves' glands have been shown to be resistant to Graves' immunoglobulins by several studies (Holmes et al. 1978; Kuzuya et al. 1980). The mechanisms being responsible for this insensitivity are currently not fully understood. We could recently demonstrate that Graves' glands obtained at surgery are not completely unresponsive to TSAb, but could well be stimulated by a minority of Graves' sera (Hörmann et al. 1986). Based on these observations the present study aims at the evaluation of various factors influencing the stimulatory effect of Graves' sera on Graves' thyroid in vitro.
Materials and Methods
Thyroid tissue was collected at surgery from 8 patients with diffuse non-toxic goitre living in an area of iodine deficiency and from 14 patients with recurrent GD.