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D. J. Carter and D. A. Heath


The urinary excretion of cyclic adenosine 3′,5′-monophosphate (cyclic AMP) was examined in patients with hyperthyroidism and primary hypothyroidism, before treatment and at least six months later on return to euthyroid status.

Urinary cyclic AMP excretion was significantly greater in the hyperthyroid group than in the hypothyroid group both in the basal state (P < 0.01) and the ambulant state (P < 0.001).

In ambulant hyperthyroid patients absolute urinary cyclic AMP excretion (μmol/24 h) was significantly greater (P < 0.05) prior to treatment than on return to euthyroid status. In the hypothyroid group no significant change occurred after treatment with 1-thyroxine (P > 0.05).

The mechanism of changes in urinary cyclic AMP excretion in thyroid disease are discussed.

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D. A. Carter, E. Saridaki and S. L. Lightman

Abstract. The plasma OT increment following stress in rats is sexually dimorphic, females exhibiting greater responses than males. We have investigated the role of neonatal androgen secretion in determining the sextypical level of response. Castration of male pups either surgically or functionally (GnRH antagonist treatment) within either 2 h or 5 days of birth did not elevate the OT responses of adult males. In contrast, androgenization of female pups (testosterone, 1.25 mg/pup) within 5 days of birth markedly reduced the OT stress responses of adults to a level insignificantly different to males. The results show that neonatal androgens can exert organizational effects on OT regulatory mechanisms. Since neonatal castration was ineffective it would appear that a prenatal defeminization or masculinization event determines OT stress responsiveness in males.