The urinary excretion of cyclic adenosine 3′,5′-monophosphate (cyclic AMP) was examined in patients with hyperthyroidism and primary hypothyroidism, before treatment and at least six months later on return to euthyroid status.
Urinary cyclic AMP excretion was significantly greater in the hyperthyroid group than in the hypothyroid group both in the basal state (P < 0.01) and the ambulant state (P < 0.001).
In ambulant hyperthyroid patients absolute urinary cyclic AMP excretion (μmol/24 h) was significantly greater (P < 0.05) prior to treatment than on return to euthyroid status. In the hypothyroid group no significant change occurred after treatment with 1-thyroxine (P > 0.05).
The mechanism of changes in urinary cyclic AMP excretion in thyroid disease are discussed.