Global epidemiology of acromegaly: a systematic review and meta-analysis

in European Journal of Endocrinology
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  • 1 S Crisafulli, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
  • 2 N Luxi, Department of Diagnostics and Public Health, University of Verona, Verona, Italy
  • 3 J Sultana, Pharmacy department, Mater Dei Hospital, Msida, Malta
  • 4 A Fontana, Unit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy
  • 5 F Spagnolo, Department of Human Pathology of Adulthood and Childhood “G. Barresi” DETEV, University of Messina, Messina, Italy
  • 6 G Giuffrida, Department of Human Pathology of Adulthood and Childhood “G. Barresi” DETEV, Division of Endocrinology, Universita degli Studi di Messina, Messina, Italy
  • 7 F Ferrau, Department of Human Pathology of Adulthood and Childhood "G. Barresi" DETEV, University of Messina, Messina, Italy
  • 8 D Gianfrilli, Section of Medical Pathophysiology, Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy
  • 9 A Cozzolino, Section of Medical Pathophysiology, Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy
  • 10 M De Martino, Dipartimento di Medicina Clinica e Chirurgia Endocrinologia e Metabolismo, Università degli Studi di Napoli Federico II, Naples, Italy
  • 11 F Gatto, Department of Endocrine and Medical Sciences, University of Genova, Genova, Italy
  • 12 F Barone-Adesi, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
  • 13 S Cannavò, Department of Human Pathology of Adulthood and Childhood “G. Barresi” DETEV, University of Messina, Messina, Italy
  • 14 G Trifirò, Department of Diagnostics and Public Health, University of Verona, Verona, 37129, Italy

Correspondence: Gianluca Trifirò, Email: gianluca.trifiro@univr.it
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Objective: To date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in literature. The aims of this study are to provide a systematic review and a meta-analysis of the global epidemiology of acromegaly and to evaluate the quality of study reporting for the identified studies.

Methods: MEDLINE, EMBASE and The Cochrane Library databases were searched for studies assessing the epidemiology of acromegaly from inception until 31st January 2020. We included original observational studies written in English, reporting acromegaly prevalence and/or incidence for a well-defined geographic area. Two reviewers independently extracted data and performed quality assessments. Prevalence and incidence pooled estimates were derived performing a random-effects meta-analysis.

Results: A total of 32 studies were included in the systematic review, and 22 of them were included in the meta-analysis. The pooled prevalence of acromegaly was 5.9 (95%CI: 4.4-7.9) per 100,000 persons, while the incidence rate (IR) was 0.38 (95%CI: 0.32-0.44) cases per 100,000 person-years. For both prevalence and IR, a considerable between-study heterogeneity was found (I2= 99.3% and 86.0%, respectively). The quality of study reporting was rated as medium for 20 studies and low for 12 studies.

Conclusions: Although the largest amount of heterogeneity was due to the high precision of the studies’ estimates, data source and geographic area could represent relevant study-levels factors which could explain about 50% of the total between-study variability. Large-scale high quality studies on the epidemiology of acromegaly are warranted to help the public health system in making decisions.

 

     European Society of Endocrinology