Multiple testing; when is many too much?

in European Journal of Endocrinology
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  • 1 R Groenwold, Clinical Epidemiology, Leids Universitair Medisch Centrum, Leiden, 2333ZA, Netherlands
  • 2 J Goeman, Biomedical Data Sciences, Leiden Universitair Medisch Centrum, Leiden, Netherlands
  • 3 S le Cessie, Medical Statistics, Leiden University Medical Centre, Leiden, 2300RC, Netherlands
  • 4 O Dekkers, Department of Clinical Epidemiology, Leids Universitair Medisch Centrum Centrum voor Humane en Klinische Genetica, Leiden, 2300 RC, Netherlands

Correspondence: Rolf Groenwold, Email:

In almost all medical research, more than a single hypothesis is being tested or more than a single relation is being estimated. Testing multiple hypotheses increases the risk of drawing a false-positive conclusion. We briefly discuss this phenomenon, which is often called multiple testing. Also, methods to mitigate the risk of false-positive conclusions are discussed.


     European Society of Endocrinology

Sept 2018 onwards Past Year Past 30 Days
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