EFFECTS OF OESTROGENS ON SERUM THYROXINE-BINDING GLOBULIN CAPACITY AND ON THE PERIPHERAL METABOLISM OF THYROXINE IN PATIENTS WITH HEPATIC CIRRHOSIS

in European Journal of Endocrinology
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ABSTRACT

The effects of oestrogens on serum thyroxine-binding globulin (TBG) capacity and on the peripheral metabolism of thyroxine were studied in patients with hepatic cirrhosis as well as in a group of normal subjects. Oestrogens increased TBG capacity in cirrhosis from 24.7 to 38.4 μg/100 ml whereas in normal subjects TBG capacity was raised from 22.8 to 48.6 μg. While the fractional turnover of thyroxine in cirrhosis did not change with the administration of oestrogens, the space of distribution was reduced. As a result of these changes, the extra-thyroidal thyroxine pool was similar to the pre-treatment values and hence the daily degradation rate of thyroxine remained unchanged.

 

     European Society of Endocrinology

Sept 2018 onwards Past Year Past 30 Days
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