Single injections of testosterone (20 mg/kg) to castrated mice caused an early stimulation in TCA-extractable fructose. Later, and at somewhat higher doses, free fructose levels were observed to rise. The earliest detectable changes occurred about 12 h following injection.
Single injections of ethinyloestradiol to recently castrated mice (48 h) caused a stimulation of prostate gland TCA-extractable fructose 12 h after hormone administration. Free fructose in these same organs was generally reduced by the administration of this oestrogen.
Ethinyloestradiol given one hour prior to a fructose stimulating dose of testosterone produced essentially the same stimulatory response as ethinyloestradiol alone.
The stimulatory action of ethinyloestradiol is probably related to changes in membrane permeability in the target organ.