ACCUMULATION AND RELEASE OF THYROID HORMONES BY THE NORMAL AND DISEASED HUMAN LIVER

in European Journal of Endocrinology
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ABSTRACT

In patients with liver cirrhosis the rate of disappearance of radioactivity from the blood during the 20 to 50 minute interval following the intravenous injection of 131I labelled L-T4 has been found to be markedly delayed compared to normal subjects. That this delay is due mainly to decreased hepatic uptake, was shown by a reduced 10 minute hepatic uptake of this labelled hormone. The principle binding proteins for T4 were not affected in a manner that would increase serum binding of the hormone. The 10 minute hepatic uptake of 131I labelled L-T3 was also reduced in the cirrhosis group, suggesting that the normal liver also contains binding sites for T3, and these are diminished in cirrhosis.

 

     European Society of Endocrinology

Sept 2018 onwards Past Year Past 30 Days
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