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CONN'S SYNDROME CAUSED BY ADRENOCORTICAL HYPERPLASIA. PATHOGENESIS OF THE SIGNS AND SYMPTOMS
in European Journal of EndocrinologyIn 1955 Conn described a syndrome caused by excessive production of aldosterone, the main manifestations being polyuria, polydipsia, hypertension, intermittent paralyses and tetany. The renal concentration power was severely disturbed, but the other renal functions were not affected to any significant degree. The serum potassium was markedly lowered, the sodium level increased, and there was a metabolic alkalosis. The latter proved not to be always present in cases observed later on (Chalmers et al., 1956). As far as we know, only adenomas or carcinomas of the adrenal cortex have so far been found in these cases.
We have treated a patient who showed practically the same syndrome and in whom an adrenocortical hyperplasia was found. As an extensive description of the clinical picture has been published in another article, only a brief outline is given here. The 17-year-old patient had suffered from polyuria and polydipsia since early childhood, but apart
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