Cortisol-producing adenoma-related somatic mutations in unilateral primary aldosteronism with concurrent autonomous cortisol secretion: their prevalence and clinical characteristics

in European Journal of Endocrinology
Authors:
Wan-Chen WuDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Kang-Yung PengDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Jin-Ying LuDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Chieh-Kai ChanDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu City, Taiwan

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Chih-Yuan WangDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Fen-Yu TsengDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Wei-Shiung YangDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Yen-Hung LinDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Po-Chih LinDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Ting-Chu ChenDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu City, Taiwan

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Kuo-How HuangDepartment of Urology, National Taiwan University Hospital, Taipei, Taiwan

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Jeff S ChuehDepartment of Urology, National Taiwan University Hospital, Taipei, Taiwan
Department of Urology, College of Medicine, National Taiwan University, Taipei, Taiwan

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Vin-Cent WuDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Correspondence should be addressed to V-C Wu; Email: q91421028@ntu.edu.tw
DOI:
https://doi.org/10.1530/EJE-22-0286
Volume/Issue:
Volume 187: Issue 4
Page Range:
519–530
Article Type:
Research Article
Online Publication Date:
14 Sep 2022
Copyright:
© European Society of Endocrinology 2022
Restricted access

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Objective

Concurrent autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) is being reported more frequently. Several somatic mutations including PRKACA, GNAS, and CTNNB1 were identified in cortisol-producing adenomas (CPAs). The presence of these mutations in unilateral PA (uPA) patients concurrent with ACS (uPA/ACS) is not well known. This study aimed to investigate the prevalence of these mutations and their clinical vs pathological characteristics in uPA/ACS.

Design

This is a retrospective cohort study.

Methods

Totally 98 uPA patients from the Taiwan Primary Aldosteronism Investigation registry having overnight 1-mg dexamethasone suppression test (DST) and adrenalectomy from 2016 to 2018 were enrolled. Their adrenal tumors were tested for PRKACA, GNAS, and CTNNB1 mutations.

Results

11 patients had CPA-related mutations (7 PRKACA and 4 GNAS). The patients carrying these mutations had higher post-DST cortisol (5.6 vs 2.6 μg/dL, P = 0.003) and larger adenoma (2.2 ± 0.3 vs 1.9 ± 0.7 cm, P = 0.025). Adenomas with these mutations had a higher prevalence of non-classical uPA (72.7% vs 26.3%, P = 0.014). Numerically, slightly more complete clinical success of uPA patients with these mutations was noticed after adrenalectomy, although it was statistically non-significant. Post-DST cortisol levels, adenoma size >1.9 cm, and the interaction of adenoma size >1.9 cm with potassium level were found to be associated with the presence of these mutations.

Conclusion

Our study showed that CPA-related mutations were detected in 36.7% of uPA/ACS adenomas. The presence of these mutations was associated with higher post-DST cortisol levels, larger adenoma sizes, and a high percentage of non-classical uPA. However, these mutations did not significantly affect the clinical and biochemical outcomes after adrenalectomy of uPA/ACS patients but they showed a better trend.

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Sept 2018 onwards Past Year Past 30 Days
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Print ISSN:
0804-4643
Online ISSN:
1479-683X

     European Society of Endocrinology

Copyright:
© European Society of Endocrinology 2022
Page(s):
12
Article Type:
Research Article
Received Date:
06 Apr 2022
Accepted Date:
19 Jul 2022
Print Publication Date:
01 Oct 2022
Online Publication Date:
14 Sep 2022
Sept 2018 onwards Past Year Past 30 Days
Abstract Views 3663 3663 16
Full Text Views 166 166 0
PDF Downloads 217 217 0
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