Ovarian and paraovarian adrenal rest tumors are not uncommon in gonadectomy materials of historical congenital adrenal hyperplasia cases in childhood

Barwick TD, Malhotra A, Webb JA, Savage MO, Reznek RH. Embryology of the adrenal glands and its relevance to diagnostic imaging. Clinical Radiology 2005 60 953–959. (https://doi.org/10.1016/j.crad.2005.04.006)

Barwick TDMalhotra AWebb JASavage MOReznek RH. Embryology of the adrenal glands and its relevance to diagnostic imaging. Clinical Radiology200560953–959. (https://doi.org/10.1016/j.crad.2005.04.006))| false
• Search Google Scholar
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Rutgers JL, Young RH, Scully RE. The testicular ‘tumor’ of the adrenogenital syndrome. A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders. American Journal of Surgical Pathology 1988 12 503–513. (https://doi.org/10.1097/00000478-198807000-00001)

Rutgers JLYoung RHScully RE. The testicular ‘tumor’ of the adrenogenital syndrome. A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders. American Journal of Surgical Pathology198812503–513. (https://doi.org/10.1097/00000478-198807000-00001))| false
• Search Google Scholar
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Stikkelbroeck NM, Otten BJ, Pasic A, Jager GJ, Sweep CG, Noordam K, Hermus AR. High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism 2001 86 5721–5728. (https://doi.org/10.1210/jcem.86.12.8090)

Stikkelbroeck NMOtten BJPasic AJager GJSweep CGNoordam KHermus AR. High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism2001865721–5728. (https://doi.org/10.1210/jcem.86.12.8090))| false
• Search Google Scholar
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Motlik K, Starka L. Adrenocortical tumour of the ovary. (A case report with particular stress upon morphological and biochemical findings). Neoplasma 1973 20 97–110.

Motlik KStarka L. Adrenocortical tumour of the ovary. (A case report with particular stress upon morphological and biochemical findings). Neoplasma19732097–110.)| false
• Search Google Scholar
• Export Citation

Russo G, Paesano P, Taccagni G, Del Maschio A, Chiumello G. Ovarian adrenal-like tissue in congenital adrenal hyperplasia. New England Journal of Medicine 1998 339 853–854. (https://doi.org/10.1056/NEJM199809173391220)

Russo GPaesano PTaccagni GDel Maschio AChiumello G. Ovarian adrenal-like tissue in congenital adrenal hyperplasia. New England Journal of Medicine1998339853–854. (https://doi.org/10.1056/NEJM199809173391220))| false
• Search Google Scholar
• Export Citation

Bas F, Saka N, Darendeliler F, Tuzlali S, Ilhan R, Bundak R, Günöz H. Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency. Journal of Pediatric Endocrinology and Metabolism 2000 13 663–667. (https://doi.org/10.1515/jpem.2000.13.6.663)

Bas FSaka NDarendeliler FTuzlali SIlhan RBundak RGünöz H. Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency. Journal of Pediatric Endocrinology and Metabolism200013663–667. (https://doi.org/10.1515/jpem.2000.13.6.663))| false
• Search Google Scholar
• Export Citation

Claahsen-van der Grinten HL, Hulsbergen-van de Kaa CA, Otten BJ. Ovarian adrenal rest tissue in congenital adrenal hyperplasia – a patient report. Journal of Pediatric Endocrinology and Metabolism 2006 19 177–182. (https://doi.org/10.1515/jpem.2006.19.2.177)

Claahsen-van der Grinten HLHulsbergen-van de Kaa CAOtten BJ. Ovarian adrenal rest tissue in congenital adrenal hyperplasia – a patient report. Journal of Pediatric Endocrinology and Metabolism200619177–182. (https://doi.org/10.1515/jpem.2006.19.2.177))| false
• Search Google Scholar
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Tiosano D, Vlodavsky E, Filmar S, Weiner Z, Goldsher D, Bar-Shalom R. Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy. Hormone Research in Paediatrics 2010 74 223–228. (https://doi.org/10.1159/000295722)

Tiosano DVlodavsky EFilmar SWeiner ZGoldsher DBar-Shalom R. Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy. Hormone Research in Paediatrics201074223–228. (https://doi.org/10.1159/000295722))| false
• Search Google Scholar
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Thomas TT, Ruscher KR, Mandavilli S, Balarezo F, Finck CM. Ovarian steroid cell tumor, not otherwise specified, associated with congenital adrenal hyperplasia: rare tumors of an endocrine disease. Journal of Pediatric Surgery 2013 48 E23–E27. (https://doi.org/10.1016/j.jpedsurg.2013.04.006)

Thomas TTRuscher KRMandavilli SBalarezo FFinck CM. Ovarian steroid cell tumor, not otherwise specified, associated with congenital adrenal hyperplasia: rare tumors of an endocrine disease. Journal of Pediatric Surgery201348E23–E27. (https://doi.org/10.1016/j.jpedsurg.2013.04.006))| false
• Search Google Scholar
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Zaarour MG, Atallah DM, Trak-Smayra VE, Halaby GH. Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy. Endocrine Practice 2014 20 e69–e74. (https://doi.org/10.4158/EP13092.CR)

Zaarour MGAtallah DMTrak-Smayra VEHalaby GH. Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy. Endocrine Practice201420e69–e74. (https://doi.org/10.4158/EP13092.CR))| false
• Search Google Scholar
• Export Citation

Chen HD, Huang LE, Zhong ZH, Su Z, Jiang H, Zeng J, Liu JC. Ovarian adrenal rest tumors undetected by imaging studies and identified at surgery in three females with congenital adrenal hyperplasia unresponsive to increased hormone therapy dosage. Endocrine Pathology 2017 28 146–151. (https://doi.org/10.1007/s12022-016-9461-4)

Chen HDHuang LEZhong ZHSu ZJiang HZeng JLiu JC. Ovarian adrenal rest tumors undetected by imaging studies and identified at surgery in three females with congenital adrenal hyperplasia unresponsive to increased hormone therapy dosage. Endocrine Pathology201728146–151. (https://doi.org/10.1007/s12022-016-9461-4))| false
• Search Google Scholar
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Bouzidi L, Triki M, Charfi S, Ameur HB, Dhaou MB, Bouaziz T, Boudawara T. Incidental finding of bilateral ovarian adrenal rest tumor in a patient with congenital adrenal hyperplasia: a case report and brief review. Pediatric and Developmental Pathology 2021 24 137–141. (https://doi.org/10.1177/1093526620980614)

Bouzidi LTriki MCharfi SAmeur HBDhaou MBBouaziz TBoudawara T. Incidental finding of bilateral ovarian adrenal rest tumor in a patient with congenital adrenal hyperplasia: a case report and brief review. Pediatric and Developmental Pathology202124137–141. (https://doi.org/10.1177/1093526620980614))| false
• Search Google Scholar
• Export Citation

Luton JP, Clerc J, Paoli V, Bonnin A, Dumez Y, Vacher-Lavenu MC. Bilateral Leydig cell tumor of the ovary in a woman with congenital adrenal hyperplasia. The first reported case. Presse Medicale 1991 20 109–112.

Luton JPClerc JPaoli VBonnin ADumez YVacher-Lavenu MC. Bilateral Leydig cell tumor of the ovary in a woman with congenital adrenal hyperplasia. The first reported case. Presse Medicale199120109–112.)| false
• Search Google Scholar
• Export Citation

Paula FJ, Dick-de-Paula I, Pontes A, Schmitt FC, Mendonca BB, Foss MC. Hyperandrogenism due to 3 beta-hydroxysteroid dehydrogenase deficiency with accessory adrenocortical tissue: a hormonal and metabolic evaluation. Brazilian Journal of Medical and Biological Research 1994 27 1149–1158.

Paula FJDick-de-Paula IPontes ASchmitt FCMendonca BBFoss MC. Hyperandrogenism due to 3 beta-hydroxysteroid dehydrogenase deficiency with accessory adrenocortical tissue: a hormonal and metabolic evaluation. Brazilian Journal of Medical and Biological Research1994271149–1158.)| false
• Search Google Scholar
• Export Citation

Al-Ahmadie HA, Stanek J, Liu J, Mangu PN, Niemann T, Young RH. Ovarian ‘tumor’ of the adrenogenital syndrome: the first reported case. American Journal of Surgical Pathology 2001 25 1443–1450. (https://doi.org/10.1097/00000478-200111000-00015)

Al-Ahmadie HAStanek JLiu JMangu PNNiemann TYoung RH. Ovarian ‘tumor’ of the adrenogenital syndrome: the first reported case. American Journal of Surgical Pathology2001251443–1450. (https://doi.org/10.1097/00000478-200111000-00015))| false
• Search Google Scholar
• Export Citation

Crocker MK, Barak S, Millo CM, Beall SA, Niyyati M, Chang R, Avila NA, Van Ryzin C, Segars J & Quezado M et al.Use of PET/CT with cosyntropin stimulation to identify and localize adrenal rest tissue following adrenalectomy in a woman with congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism 2012 97 E2084–E2089. (https://doi.org/10.1210/jc.2012-2298)

Crocker MKBarak SMillo CMBeall SANiyyati MChang RAvila NAVan Ryzin CSegars JQuezado MUse of PET/CT with cosyntropin stimulation to identify and localize adrenal rest tissue following adrenalectomy in a woman with congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism201297E2084–E2089. (https://doi.org/10.1210/jc.2012-2298))| false
• Search Google Scholar
• Export Citation

Fernandez-Garcia Salazar R, Munoz-Darias C, Haro-Mora JJ, Almaraz MC, Audi L, Martinez-Tudela J, Yahyaoui R, Esteva I. Woman with virilizing congenital adrenal hyperplasia and Leydig cell tumor of the ovary. Gynecological Endocrinology 2014 30 549–552. (https://doi.org/10.3109/09513590.2014.907260)

Fernandez-Garcia Salazar RMunoz-Darias CHaro-Mora JJAlmaraz MCAudi LMartinez-Tudela JYahyaoui REsteva I. Woman with virilizing congenital adrenal hyperplasia and Leydig cell tumor of the ovary. Gynecological Endocrinology201430549–552. (https://doi.org/10.3109/09513590.2014.907260))| false
• Search Google Scholar
• Export Citation

Sisto JM, Liu FW, Geffner ME, Berman ML. Para-ovarian adrenal rest tumors: gynecologic manifestations of untreated congenital adrenal hyperplasia. Gynecological Endocrinology 2018 34 644–646. (https://doi.org/10.1080/09513590.2018.1441399)

Sisto JMLiu FWGeffner MEBerman ML. Para-ovarian adrenal rest tumors: gynecologic manifestations of untreated congenital adrenal hyperplasia. Gynecological Endocrinology201834644–646. (https://doi.org/10.1080/09513590.2018.1441399))| false
• Search Google Scholar
• Export Citation

Stikkelbroeck NM, Hermus AR, Schouten D, Suliman HM, Jager GJ, Braat DD, Otten BJ. Prevalence of ovarian adrenal rest tumours and polycystic ovaries in females with congenital adrenal hyperplasia: results of ultrasonography and MR imaging. European Radiology 2004 14 1802–1806. (https://doi.org/10.1007/s00330-004-2329-x)

Stikkelbroeck NMHermus ARSchouten DSuliman HMJager GJBraat DDOtten BJ. Prevalence of ovarian adrenal rest tumours and polycystic ovaries in females with congenital adrenal hyperplasia: results of ultrasonography and MR imaging. European Radiology2004141802–1806. (https://doi.org/10.1007/s00330-004-2329-x))| false
• Search Google Scholar
• Export Citation

Baranetsky NG, Zipser RD, Goebelsmann U, Kurman RJ, March CM, Morimoto I, Stanczyk FZ. Adrenocorticotropin-dependent virilizing paraovarian tumors in Nelson’s syndrome. Journal of Clinical Endocrinology and Metabolism 1979 49 381–386. (https://doi.org/10.1210/jcem-49-3-381)

Baranetsky NGZipser RDGoebelsmann UKurman RJMarch CMMorimoto IStanczyk FZ. Adrenocorticotropin-dependent virilizing paraovarian tumors in Nelson’s syndrome. Journal of Clinical Endocrinology and Metabolism197949381–386. (https://doi.org/10.1210/jcem-49-3-381))| false
• Search Google Scholar
• Export Citation

Verdonk C, Guerin C, Lufkin E, Hodgson SF. Activation of virilizing adrenal rest tissues by excessive ACTH production. An unusual presentation of Nelson’s syndrome. American Journal of Medicine 1982 73 455–459. (https://doi.org/10.1016/0002-9343(8290753-7)

Verdonk CGuerin CLufkin EHodgson SF. Activation of virilizing adrenal rest tissues by excessive ACTH production. An unusual presentation of Nelson’s syndrome. American Journal of Medicine198273455–459. (https://doi.org/10.1016/0002-9343(8290753-7))| false
• Search Google Scholar
• Export Citation

Speiser PW, Arlt W, Auchus RJ, Baskin LS, Conway GS, Merke DP, Meyer-Bahlburg HFL, Miller WL, Murad MH & Oberfield SE et al.Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism 2018 103 4043–4088. (https://doi.org/10.1210/jc.2018-01865)

Speiser PWArlt WAuchus RJBaskin LSConway GSMerke DPMeyer-Bahlburg HFLMiller WLMurad MHOberfield SECongenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism20181034043–4088. (https://doi.org/10.1210/jc.2018-01865))| false
• Search Google Scholar
• Export Citation

Claahsen-van der Grinten HL, Duthoi K, Otten BJ, d’Ancona FC, Hulsbergen-vd Kaa CA, Hermus AR. An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency. European Journal of Endocrinology 2008 159 489–491. (https://doi.org/10.1530/EJE-08-0311)

Claahsen-van der Grinten HLDuthoi KOtten BJd’Ancona FCHulsbergen-vd Kaa CAHermus AR. An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency. European Journal of Endocrinology2008159489–491. (https://doi.org/10.1530/EJE-08-0311))| false
• Search Google Scholar
• Export Citation

Paulino Mda Mda C, Steinmetz L, Menezes Filho HC, Kuperman H, Della Manna T, Vieira JG, Blasbalg R, Baroni R, Setian N, Damiani D. Search of prostatic tissue in 46,XX congenital adrenal hyperplasia. Arquivos Brasileiros de Endocrinologia e Metabologia 2009 53 716–720. (https://doi.org/10.1590/s0004-27302009000600004)

Paulino Mda Mda CSteinmetz LMenezes Filho HCKuperman HDella Manna TVieira JGBlasbalg RBaroni RSetian NDamiani D. Search of prostatic tissue in 46,XX congenital adrenal hyperplasia. Arquivos Brasileiros de Endocrinologia e Metabologia200953716–720. (https://doi.org/10.1590/s0004-27302009000600004))| false
• Search Google Scholar
• Export Citation

Doherty PJ, Friedman AA, Migeon CJ, Macura KJ, Salmasi AH, Lakshmanan Y. Absence of prostatic growth in large cohort of adult female patients with congenital adrenal hyperplasia. Journal of Urology 2012 188 1588–1595. (https://doi.org/10.1016/j.juro.2012.02.029)

Doherty PJFriedman AAMigeon CJMacura KJSalmasi AHLakshmanan Y. Absence of prostatic growth in large cohort of adult female patients with congenital adrenal hyperplasia. Journal of Urology20121881588–1595. (https://doi.org/10.1016/j.juro.2012.02.029))| false
• Search Google Scholar
• Export Citation

Reichman DE, White PC, New MI, Rosenwaks Z. Fertility in patients with congenital adrenal hyperplasia. Fertility and Sterility 2014 101 301–309. (https://doi.org/10.1016/j.fertnstert.2013.11.002)

Reichman DEWhite PCNew MIRosenwaks Z. Fertility in patients with congenital adrenal hyperplasia. Fertility and Sterility2014101301–309. (https://doi.org/10.1016/j.fertnstert.2013.11.002))| false
• Search Google Scholar
• Export Citation

Cabrera MS, Vogiatzi MG, New MI. Long term outcome in adult males with classic congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism 2001 86 3070–3078. (https://doi.org/10.1210/jcem.86.7.7668)

Cabrera MSVogiatzi MGNew MI. Long term outcome in adult males with classic congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism2001863070–3078. (https://doi.org/10.1210/jcem.86.7.7668))| false
• Search Google Scholar
• Export Citation