Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults

in European Journal of Endocrinology
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  • 1 Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
  • 2 Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • 3 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • 4 Department of Radiology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
  • 5 Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
  • 6 National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
  • 7 Department of Clinical biochemistry, Rigshospitalet
  • 8 NNF Center for Protein Research, Rigshospitalet
  • 9 Department of Public Health, Rigshospitalet
  • 10 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • 11 Steno Diabetes Center Copenhagen, Gentofte, Denmark

Correspondence should be addressed to F K Knop; Email: filip.krag.knop.01@regionh.dk
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Aims/hypothesis

Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumption) in young, healthy males.

Methods

Fourteen festival participants (FP) were studied before, during and after 1 week’s participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.

Results

The FP group consumed more alcohol compared to their standard living conditions (2.0 ± 3.9 vs 16.3 ± 8.3 units/day, P < 0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (206 ± 24 vs 236 ± 17 min × nmol/L, P = 0.052) and the Matsuda index of insulin sensitivity decreased (6.2 ± 2.4 vs 4.7 ± 1.4, P  = 0.054). AUC for glucagon during oral glucose tolerance test (OGTT) increased in the FP group (1037 ± 90 vs 1562 ± 195 min × pmol/L, P = 0.003) together with fasting fibroblast growth factor 21 (FGF21) (62 ± 30 vs 132 ± 72 pmol/L, P < 0.001), growth differentiation factor 15 (GDF5) (276 ± 78 vs 330 ± 83 pg/mL, P = 0.009) and aspartate aminotransferase (AST) levels (37.6 ± 6.8 vs 42.4 ± 11 U/L, P = 0.043). Four participants (29%) developed ultrasound-detectable steatosis and a mean strain elastography-assessed liver stiffness increased (P = 0.026) in the FP group.

Conclusions/Interpretation

Participation in Roskilde Festival did not affect oral glucose tolerance but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.

Supplementary Materials

    • Supplementary Table 1. Biochemical profiles of festival participants and control subjects. TG, Triglycerides; TC, total cholesterol; HDL, high-density lipoproteins; LDL, low-density lipoproteins; VLDL, very-low-density lipoproteins; ALT, alanine amino transferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transferase; CRP, C-reactive protein; IFN-&#x03B3;, interferon gamma; LBP, lipopolysaccharide binding protein; IL-1&#x03B2;, interleukin 1 beta; IL-8, interleukin 8; IL-10, interleukin 10; TNF-&#x03B1;, tumor necrosis factor-&#x03B1;

 

     European Society of Endocrinology

Sept 2018 onwards Past Year Past 30 Days
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