Carotid body chemosensitivity: early biomarker of dysmetabolism in humans

in European Journal of Endocrinology
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  • 1 CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal
  • 2 ciTechCare, Escola Superior de Saúde de Leiria, Instituto Politécnico de Leiria, Leiria, Portugal
  • 3 Serviço de Cardiologia, Hospital Santa Marta, Centro Hospital Lisboa Central, EPE, Lisbon, Portugal

Correspondence should be addressed to S V Conde; Email: silvia.conde@nms.unl.pt

*(J P Cunha-Guimaraes and M P Guarino contributed equally to this work)

(M Mota-Carmo and S V Conde are joint senior authors)

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Objective

The carotid bodies (CBs) are peripheral chemoreceptor organs classically described as being O2 sensors, which are increasingly emerging as core players in metabolic control. Herein we evaluated CB activity in prediabetes patients and determined its correlation with dysmetabolism clinical features.

Design and methods

Prediabetes patients were recruited at the Cardiology Service, Hospital Santa Marta, Centro Hospitalar Lisboa Central, EPE (CHLC-EPE). The study was approved by CHLC-EPE and NOVA Medical School Ethics Committee. Thirty-three prediabetic and 14 age-matched, non-prediabetic, volunteers had their peripheral chemosensitivity evaluated by the Dejours test. Serum biomarkers of metabolic disease, insulin sensitivity (HOMA-IR), blood pressure, carotid intima-media thickness (cIMT) and glucose tolerance were assessed.

Results

CB chemosensitivity was significantly increased in prediabetic group (P < 0.01). Fasting blood, glucose intolerance, fasting insulin and HOMA-IR were significantly higher in prediabetes patients. Insulin resistance correlated both with peripheral chemosensitivity, assessed by the Dejours test (P < 0.05) and with abdominal circumference (P < 0.01). HbA1c correlated with HOMA-IR (P < 0.05) and left cIMT (P < 0.05) in prediabetes patients.

Conclusions

We conclude that CB is overactive in prediabetes subjects and that peripheral chemosensitivity correlates with fasting insulin and insulin resistance representing a novel non-invasive functional biomarker to forecast early metabolic disease.

Supplementary Materials

    • Table 1 Supplemental: Spearman correlations between peripheral chemosensitivity evaluated by Dejour Test and other demographic and biological variables. CIMT- carotid intima-media thickness. Value represent mean &#x00B1; standard deviation (SD) * p<0.05, **p<0.01.

 

     European Society of Endocrinology

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