Nocturnal urinary growth hormone excretion in children with short stature

in European Journal of Endocrinology
Restricted access

Abstract. Nocturnal urinary growth hormone levels in children with short and normal stature were measured by a sensitive enzyme immunoassay. Urinary GH excretion during sleep correlated positively with peak plasma GH values during pharmacological (r = 0.74, P < 0.001) and sleep (r = 0.85, P < 0.001) tests. The amounts of urinary GH excretion during sleep differed significantly from each other in the following groups: complete GH deficiency (mean ± sem: 0.1 ± 0.1 ng/m2 of body surface area; range: < 0.1–0.4), partial GH deficiency (1.6 ± 0.3 ng/m2; 0.2–3.1), and short stature without GH deficiency (3.7 ± 0.6 ng/m2; 0.7–11.5). No significant difference was found between short stature without GH deficiency and normal stature (5.0 ± 0.5 ng/m2; 2.1 – 10.5). Measurement of nocturnal urinary GH excretion is a simple method for screening of GH excretion and may be helpful in the differentiation of the various etiologies of short stature in children.

 

     European Society of Endocrinology

Related Articles

Article Information

Metrics

All Time Past Year Past 30 Days
Abstract Views 45 45 0
Full Text Views 58 58 0
PDF Downloads 52 52 0

Altmetrics

Cited By

PubMed

Google Scholar