Specific and weight loss-associated effects of one-week exposure to ethanol on pituitary-gonadal function of male rats

in European Journal of Endocrinology
Restricted access

Abstract. We studied the effects of one-week ethanol exposure (2.2 g/kg twice daily) on pituitary-gonadal functions of male rats. Because ethanol decreases the food-intake of the animals, diet-restricted rats were used as controls. Testicular LH and PRL receptors of ethanol-treated rats were significantly (P <0.05–0.01) reduced in comparison with weight-matched controls. In contrast, testicular GnRH receptors of the ethanol group were increased (P <0.05). Testicular FSH binding, pituitary GnRH-receptors, and serum gonadotropins and testosterone were not affected by ethanol. The present results demonstrate a specific effect of ethanol on testicular LH and PRL receptors which, unlike some other endocrine changes during ethanol expoure, is not due to a concomitant weight loss. In addition, the results suggest a concurrent change in the putative testicular GnRH receptor associated paracrine regulation, as implied by increased testicular GnRH binding upon ethanol exposure.


     European Society of Endocrinology

Related Articles

Article Information


All Time Past Year Past 30 Days
Abstract Views 87 87 1
Full Text Views 82 26 0
PDF Downloads 44 18 0


Cited By


Google Scholar