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BIOLOGICAL METHODS FOR DETERMINATION OF POTENCY OF GROWTH HORMONE PREPARATIONS
in European Journal of EndocrinologyTwo papers published recently in this journal by Dingemanse, Freud & Uyldert (p. 71, 1948) and by Gjeddebæk (p. 258, 1948) discuss the various biological methods for determining the potency of growth hormone preparations.
Dingemanse et al. propose to designate the growth hormone as chondrotrophin and prefer to speak of chondrotrophin rather than somatotrophin (Selye). The reason for introducing the new expression chondrotrophin is, however, not quite obvious. No evidence at all proves the existence of an independent chondrotrophic hormone or preparation, such a substance has not been isolated yet.
The typical many-sided effect of growth hormone preparations has, as regards hereditary pituitary dwarfism in mice, been proved many years ago by Kemp in a paper, published 1934, also demonstrating for the first time the possibility of using dwarf mice for potency determinations of growth hormone preparations. In this publication Kemp (1. c. p. 1855) emphasises: »... dass bei Zwergmäusen
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